颈动脉内中膜厚度与糖耐量减低的相关性研究

Relationship between carotid intima-media thickness and impaired glucose tolerance

目的:探讨颈动脉内中膜厚度(CIMT)与糖耐量减低(IGT)的相关性。方法:超声自动测量150例糖耐量减低的人群和130例健康对照者的双侧颈总动脉内中膜厚度、血管内径,同时测定各组生化指标。结果:糖耐量减低组的体质指数(BMI)、空腹血糖(FPG)、餐后2 h血糖(2-hPG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)平均CIMT较对照组明显增高(P<0.01)。糖耐量减低组的性别、年龄、HDL-C、内径与对照组间无明显差异(P>0.05)。两组间左、右侧内中膜厚度无明显差异(P>0.05)。结论:糖耐量减低人群颈动脉内中膜厚度显著增加,表明动脉粥样硬化改变早在糖耐量减低阶段就已开始。

Objective：To explore the relationship between carotid intima-media thickness（CIMT） and impaired glucose tolerance（IGT）.Methods：One hundred and fifty subjects in IGI group and 130 controls were included.IMT and diameter of bilateral common carotid artery were measured by ultrasound automatically.Some biochemical parameters were measured simultaneously.Results：BMI,FPG,2-hPG,TC,LDL-C,TG and the average CIMT of IGT group were higher than that of control group（P 〈 0.01）.There was no significant difference in sex,age,HDL-C,diameter and CIMT on righ and left sides between two groups（P 〉 0.05）.Conclusion：CIMT increased in people with IGT remarkably,which implies that the onset of atherosderotic lesion in them.