CRP基因C+1444T多态性与中国苏皖地区汉族人群ACS的易感性无关

No association of C-reaction protein gene C+1444T polymorphisms with acute coronary syndrome in Chinese Han population of Suwan region

目的:探讨C反应蛋白(C-reactive portein,CRP)基因C+1444T多态性与急性冠脉综合征(acute coronary syndrome,ACS)的易感性。方法:选择2003年11月～2008年5月住院的ACS患者443例(ACS组)和同期经冠脉造影排除冠心病者285例(对照组),采用聚合酶链反应-限制性片段长度多态性(PCR-RELP)方法检测CRP基因C+1444T多态性。结果:ACS组的CC、CT和TT基因型以及C等位基因频率分布与对照组无显著性差异(83.7%vs 86.7%、14.4%vs 12.3%、1.8%vs 1.1%和91.0%vs 92.8%,P值分别为0.292、0.439、0.540和0.243)。调整年龄、性别、吸烟、收缩压、舒张压、血糖和血脂等多因素后采用多元Logistic回归分析显示,CRP基因C+1444T多态性与ACS的发生仍无显著性关联(P>0.05)。结论:在中国苏皖地区汉族人群中,CRP基因C+1444T多态性与ACS的易感性无显著相关性。

Objective：To investigate the susceptibity of C-reaction protein（CRP） gene C＋1444T polymorphisms to acute coronary syndrome（ACS）.Methods：From Nov 2003 to May 2008,443 inpatients with ACS（ACS group） were recruited,the control group was consisted of 285 subjects who were free of coronary artery disease confirmed by coronary angiography.The CRP gene C＋1444T polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphisms analysis.Results：There were no significant differences in the frequencies of CC,CT and TT genotype between ACS group and control group（83.7% vs 86.7%,14.4% vs 12.3% and 1.8% vs 1.1%,P were 0.292,0.439 and 0.540,respectively）.The prevalence of C allele were 91.0% and 92.8% for ACS group and control group,respectively（P=0.243）.Furthermore,after adjusted for multiple factors such as age,sex,smoking,systolic pressure,diastolic pressure,blood glucose,and blood lipids,the multivariate logistic regression analysis indicated that there was no significant correlation between the CRP gene C＋1444T polymorphisms and ACS（P 0.05）.Conclusion：The present findings suggest that the CRP gene C＋1444T polymorphisms may be no related to ACS susceptibility in the Chinese Han population of Suwan region.