CK和VEGF在舌鳞癌淋巴结微转移中的表达及意义

Significance of CK and VEGF Expression in Lymph Node Micrometastasis of tongue squamous cell carcinoma

目的:研究细胞角蛋白(CK-AE1/AE3)、血管内皮细胞生长因子(VEGF)在舌鳞状细胞癌(舌鳞癌)患者清扫淋巴结中的表达及与舌鳞癌患者预后的关系。方法:应用免疫组化S-P法检测60例舌鳞癌患者VEGF表达及其清扫淋巴结178个CK表达。结果:29个淋巴结常规病理检查未发现转移者,CK表达阳性。随着肿瘤T分期的增加,淋巴结CK表达阳性率也增加,有淋巴结转移组的VEGF表达明显高于无淋巴结转移组,其阳性率也随临床分期增加而增加。结论:CK与VEGF可作为协同判断舌鳞癌微转移及进展程度与预后的指标。

Objective： This study aims to explore the relationship between the CK（AE1/AE3） and VEGF protein expression and prognosis among tongue squamous cell carcinoma.Methods：Immunohistochemical technique was used to determine the expression of VEGF in 60 squamous cell carcinoma and the expression of CK in dissected lymph nodes.Results：there were positive expression of CK in 29 none lymph nods dissection patients,and positive ratios of CK in lymph nodes dissection patients higher than that in none lymph nodes dissection patients.All positive ratios of CK increased wish the development of T stage.Conclusion：Both CK and VEGF could be used as helpful markers to diagnose the micrometastasis and predict the prognosis of tongue squamous cell carci.