口腔鳞状细胞癌中血管生成拟态的研究

Study on Vasculogenic Mimicry in Oral Squamous Cell Carcinoma

目的:探讨口腔鳞状细胞癌(OSCC)中是否存在血管生成拟态(VM),观察其组织形态学特征、领域分布情况,分析其形成规律,并进一步阐述VM存在的临床意义。方法:筛选106例OSCC石蜡标本,进行CD34免疫组化染色结合过碘酸雪夫氏反应(PAS反应)双重染色检测OSCC中是否存在VM。结果:在106例OSCC患者发现15.09%(16/106)存在VM。VM与患者性别、年龄、淋巴结转移无关,与肿瘤组织分化程度有关,有VM组的OS-CC分化程度低于无VM组OSCC(χ2/Z=2.0340,P<0.05),差异有统计学意义。结论:OSCC中存在VM,恶性度越高OSCC形成拟态的能力越强。血管生成拟态参与口腔鳞状细胞癌血液供给,起到"替代供养器"的作用。

Objective：To investigate if vasculogenic mimicry（VM） exists in oral squamous cell carcinoma（OSCC） and to explore its clinical significance.Methods：One hundred and twenty-four OSCC resection specimens were underwent HE staining and double staining of CD34 and PAS to observe the existence of VM.Results：15.09%（16 specimens） of the 106 specimens exhibited evidence of VM.VM was not correlated with age,sex and existence of lymph node metastasis;but was associated with differentiation degree.The low differentiated OSCC exhibited more VM specimens than the high differentiated OSCC（χ2/Z=2.0340,P0.05）.Conclusion：VM exists in OSCC,and the higher invasive OSCCs exhibit more VM than the less invasive ones.VM involves in the blood supply of oral squamous cell carcinoma,and plays a role of ＂alternative support device＂.