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微小RNA与免疫调节 被引量：2

microRNAs:Novel regulators during the immune response
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摘要 微小RNA(miRNA)是一类22核苷酸的高度保守的小分子非编码RNA,主要通过与靶mRNA的3′非编码区碱基互补配对结合而引起靶RNA降解或翻译抑制。越来越多的研究显示,miRNA在免疫反应中具有新型调节作用,包括调节免疫细胞的发育和分化、B细胞抗体的产生、炎性介质的释放、细胞信号转导等。miRNA在维持机体免疫系统的自稳和免疫相关疾病发生中的作用也逐渐受重视。本文综述了miRNA调节固有性和适应性免疫反应功能和机制的研究进展。 microRNA（miRNA）,which is an abundant class of 22nt highly conversed,small non-coding RNA,can make mRNA degradation or influence mRNA translation via a complementary binding with the 3＇-UTR of the miRNA.Recently,more studies have shown that the effects of these non-coding small RNAs on immune system development and response,and also that miRNA is involved in the regulation of immunity,including the development and differentiation of immune cells,antibody production,inflammatory mediator release,and signal transduction in cells.miRNA is considered to play a role in maintaining the homeostasis of immune system and in immune-associated diseases.Here,the latest findings are summarized to explore the function and mechanism of miRNA in modulating innate and adaptive immune responses.
作者 王琳 谢青
机构地区 上海交通大学医学院附属瑞金医院感染科
出处 《微生物与感染》 2011年第1期39-43,共5页 Journal of Microbes and Infections
基金 "十一五"国家科技重大专项(2008ZX10002-005 2008ZX10002-007 2008ZX09312-007) 国家自然科学基金(30872252) 上海市科委基础研究重点项目(08JC1415300)
关键词 微小RNA 免疫反应 调节 microRNA Immune response Regulation
分类号 R392.1 [医药卫生—免疫学]
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参考文献12

  • 1Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K,Rudensky AY. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T ceils by targeting SOCS1 protein [J]. Immunity, 2009, 30(1): 80-91.
  • 2Pedersen IM, Otero D, Kao E, Miletic AV, Hother C, Ralfkiaer E, Rickert RC, Gronbaek K, David M. Onco- miR-155 targets SHIP1 to promote TNFa-dependent growth of B cell lymphomas [J]. EMBO Mol Med, 2009, 1 (5): 288-295.
  • 3Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B, Fabbri M, Alder H, Liu CG, Calin GA, Croce CM. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock [J]. J Immunol, 2007, 179(8) : 5082-5089.
  • 4Dorsett Y, McBride KM, Jankovic M, Gazumyan A, ThaiTH, Robbiani DF, Di Virgilio M, Reina San-Martin B, Heidkamp G, Schwickert TA, Eisenreich T, Rajewsky K, Nussenzweig MC. MicroRNA-155 suppresses activation- induced cytidine deaminase-mediated Myc-Igh translocation [J]. Immunity, 2008, 28(5): 630-638.
  • 5Kluiver J, Poppema S, de Jong D, Blokzijl T, Harms G, Jacobs S, Kroesen BJ, van den Berg A. BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas [J]. J Pathol, 2005, 207(2) : 243-249.
  • 6Tang Y, Luo X, Cui H, Ni X, Yuan M, Guo Y, Huang X, Zhou H, de Vries N, Tak PP, Chen S, Shen N.MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins [J]. Arthritis Rheum, 2009, 60(4): 1065-1075.
  • 7Taganov KD, Boldin MP, Chang KJ, Baltimore D. NF- kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses[J]. Proc Natl Acad Sci USA, 2006, 103 (33): 12481-12486.
  • 8Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis ML, Nervi C, Bozzoni I. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/ EBPalpha regulates human granulopoiesis [J]. Cell, 2005, 123(5) : 819-831.
  • 9Baltimore D, Boldin MP, O' Connell RM, Rao DS, Taganov KD. MicroRNAs: new regulators of immune cell development and function[J]. Nat Immunol, 2008, 9(8): 839-845.
  • 10Costinean S, Zanesi N, Pekarsky Y, Tili E, Volinia S, Heerema N, Croce CM. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eu-miR155 transgenic mice [J]. Proc Natl Acad Sci USA, 2006, 103 (18) : 7024-7029.

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微生物与感染
2011年 第1期

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