摘要
Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achieved. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. Several therapeutic strategies have evolved, including gene-based (tumor suppressor genes, suicide genes, antiangiogenic genes, cytokine and oxidative stress-based genes) and RNA-based (antisense oligonucleotides and RNA interference) approaches. In addition, immune response-based strategies (dendritic cell- and T cell-based therapy) are also under investigation in tumor gene therapy. This review highlights the progress and recent developments in gene delivery systems, therapeutic strategies, and possible clinical directions for gene therapy.
Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achieved. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. Several therapeutic strategies have evolved, including gene-based （tumor suppressor genes, suicide genes, antiangiogenic genes, cytokine and oxidative stress-based genes） and RNA-based （antisense oligonucleotides and RNA interference） approaches. In addition, immune response-based strategies （dendritic cell- and T cell-based therapy） are also under investigation in tumor gene therapy. This review highlights the progress and recent developments in gene delivery systems, therapeutic strategies, and possible clinical directions for gene therapy.
基金
supported by Foundation from Knowl edge Innovation Program in CAS (No. KSCX1-YW-R-10)
National Natural Science Foundation of China(No. 30973448)
关键词
肿瘤基因治疗
非病毒载体
RNA干扰
肿瘤抑制基因
反义寡核苷酸
抗血管生成
树突状细胞
肿瘤治疗
Gene therapy, RNA interference, antisense RNA, tumor suppressor gene, suicide gene, oxidative stress, dendritic cells, angiogenesis, viral vector, non-viral vector
