骨质疏松性椎体脱矿化生物力学模型的研究进展

Research progress in biomechanical models using demineralized osteoporotic vertebra body

骨质疏松椎体脱矿化模型为骨质疏松模型的研究提出了一个新方向,利用脱钙液可与椎体中钙质结合,导致钙质流失、骨矿含量下降,从而使得椎体标本的骨密度下降,同时出现与体内骨质疏松状态下的生物力学性能相似的变化。骨质疏松椎体脱矿化模型能在短时间内建立,有利于及时反馈实验信息,缩短研究周期,并为进一步在体内骨质疏松动物模型的研究提供参考依据,为新型器械及新型手术方法提供可靠的生物力学测试平台。

Demineralized osteoporotic vertebra model raised a new direction for osteoporosis research. With decalcificating solution binding to calcium in the vertebra body, calcium could be deleted from the vertebrae resulting in a loss of calcium and decrease of bone mineral content. Bone mineral density in the vertebra specimen decreased, leading to biomechanical changes similar to those in osteoporosis in vivo. The model could be established in a short time, in favor of the feedback of experimental information and the shortening of research period. It could provide research reference for in vivo osteoporosis studies by the animal model. It could also provide a reliable platform of biomechanical testing for new instruments and surgical techniques.