非酒精性脂肪肝与外周动脉硬化的关系

The Relationship Between Non-Alcoholic Fatty Liver and Peripheral Atherosclerosis

目的探讨非酒精性脂肪肝与外周动脉硬化的关系。方法选取进行健康体检的300名体检者进入研究,其中非酒精性脂肪肝体检者138例,无非酒精性脂肪肝体检者162例,两组年龄、性别构成差异无显著性。测定相关的人体测量学指标、臂踝脉博波速度、踝臂指数和经超声测定脂肪肝。结果非酒精性脂肪肝组体重、体质指数、腰围、臂踝脉博波速度、收缩压、舒张压、脉压、丙氨酸氨基转移酶及天冬氨酸氨基转移酶水平均高于无非酒精性脂肪肝组(P<0.05),且非酒精性脂肪肝组肥胖、高血压及外周动脉硬化检出率明显高于无非酒精性脂肪肝组(P<0.01)。多因素Logistic回归分析显示,体质指数、臂踝脉博波速度、丙氨酸氨基转移酶为非酒精性脂肪肝的易患危险因素。结论臂踝脉博波速度与非酒精性脂肪肝密切相关,非酒精性脂肪肝与外周动脉硬化之间有着密切的关系。

Aim To investigate the relationship between non-alcoholic fatty liver（NAFL） and peripheral atherosclerosis. Methods 300 physical examines had selected to enter the study.All participants were divided into NAFL group and non-NAFL group,NAFL group included 138 cases,non-NAFL group included 162 cases. Age and gender composition had no significant difference in the two groups（P0.05）. Anthropometry indicators,brachial-ankle pulse wave velocity（baPWV） and ankle-brachial index were measured. Fatty liver was measured via ultrasonography. Results Weight,body mass index（BMI）,waistline,baPWV,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,pulse pressure（PP）,alanine aminotransferase（ALT）,aspartate aminotransferase（AST） were significantly higher in the NAFL group than those in the non-NAFL group（P0.05）. The detection rates of obesity,hypertension and peripheral atherosclerosis in the NAFL group were significantly higher than those in the non-NAFL group（P0.01）.Logistic regression analysis showed that BMI,baPWV and ALT were susceptible factors of NAFL. Conclusion baPWV is closely associated with NAFL. There is a close relationship between NAFL and peripheral atherosclerosis.