阴茎癌患者年龄和腹股沟淋巴结转移概率的关系

The Relationship Between Age and Probability of Inguinal Lymph Node Metastases in Penile Cancer

目的:探讨阴茎癌患者年龄和腹股沟淋巴结转移概率的关系。方法:我们回顾性分析110例腹股沟淋巴结临床阴性的阴茎鳞状细胞癌患者。通过局部加权回归散点平滑法(LOWESS)分析年龄和腹股沟淋巴结转移概率的关系。根据欧洲泌尿外科阴茎癌指南,将患者分为不同的转移风险组,随后比较不同转移风险组下各个年龄段的淋巴结转移概率。结果:本组患者中位年龄为54岁,最小者20岁,最大者75岁。淋巴结转移的概率大致呈现抛物线的形状:在<40和>60岁时较高,40～60岁时较为稳定。在淋巴结转移风险中危组和高危组,<40岁和>60岁组的淋巴结转移概率均高于40～60岁组。结论:阴茎癌的淋巴结转移概率随年龄变化而呈现<40岁和>60岁组增高的趋势,进一步的研究需要揭示不同年龄段肿瘤的特定分子生物学改变。

Objective：To investigate the relationship between age and the probability of inguinal lymph node metastases （LNM） in penile cancer patients. Methods.. We retrospectively reviewed 110 penile squamous cell carcinoma patients with clinical node-negative disease. The relationship between age and probability of inguinal LNM was analyzed by locally weighted scatterplot smoothing. We stratified the patients into different risk groups according to the European Association of Urology （EAU） penile cancer guideline. The incidences of LNM in different age groups were evaluated in every risk groups. Results： The median age of the patients was 54 years old, range from 20 to 75 years old. The relationship between age and probability of LNM was a parabola. The incidence was higher in patients %40 years old or ）60 years old than those 40-60 years old. The differences were also observed in EAU intermediate and high risk groups. Conclusions： The probabilities of inguinal LNM were higher in penile cancer patients %40 years old or ）60 years old than those 40-60 years old. Further study should investigate the molecular changes in different age groups.