老年人血镁水平降低与血糖代谢异常的关系

Hypomagnesemia associated with glucose metabolism disorders in the elderly

目的 探讨老年人血镁水平降低与血糖代谢异常的关系.方法 收集我院门诊126例老年人的查体资料,其中2型糖尿病患者50例,糖调节异常者35例,血糖正常者41例,对3组老年人临床资料进行比较分析.结果 （1）3组的年龄、体质指数、血脂水平差异均无统计学意义,糖尿病组和糖调节异常组血清镁明显低于血糖正常组,分别为（0.75±0.11）mmol/L和（0.78±0.12）mmol/L对（0.84±0.1）mmol/L,差异有统计学意义（P＜0.01、＜0.05）;（2）低血镁发病率在2型糖尿病和糖调节异常组明显高于血糖正常组,分别为24.0%和28.6%对7.3%（均为P＜0.01）;（3）相关分析结果显示,血镁水平与空腹血糖及糖化血红蛋白水平呈明显负相关（r=-0.343、-0.271,均为P＜0.01）,与年龄及体质指数无相关.结论 老年人血清镁水平降低与血糖代谢异常有关.

Objective To explore the relationship between serum magnesium （Mg） levels and glucose metabolism disorders in the elderly.Methods The data of health examination of 126 elderly people were collected in our hospital.There were 50 patients with type 2 diabetes,35 patients with impaired glucose regulation （IGR） and 41 people with normal glucose.The clinical data of the three groups were compared and analyzed.Results （1）There were no significant differences in age,body mass index （BMI） and blood lipid level among the three groups.The mean serum Mg level was lower in normal glucose group [（0.84±0.1） mmol/L] than in diabetic group [（0.75±0.11） mmol/L,P〈0.01] and IGR group [（0.78±0.12） mmol/L,P〈0.05].（2）The prevalence of hypomagnesemia was higher in diabetic group and IGR group than in normal glucose group （24%,28.6% vs.7.3%,P〈 0.01 ）.（3）The correlation study showed that the serum magnesium level was negatively associated with fasting plasma glucose and HbA1c （r= - 0.343,- 0.271,P〈0.01 ）,but not associated with age and BMI.Conclusions The low serum magnesium level is associated with glucose metabolism disorders in the elderly.