组蛋白去乙酰化酶抑制剂在乳腺癌内分泌治疗上的研究进展
摘要
组蛋白乙酰化、去乙酰化修饰是基因转录调控的关键机制之一,与肿瘤的发生、发展关系密切。乳腺癌是女性肿瘤中最常见的肿瘤之一,内分泌治疗是其主要治疗手段之一,但原发性和继发性内分泌治疗耐药极大地影响了治疗的效果,在体内外研究中证实组蛋白去乙酰化酶抑制剂(histone deacetylase inhibitors,HDACis)具有增敏内分泌治疗及逆转内分泌治疗耐药的作用,为提高内分泌治疗效果提供了新的选择。
出处
《实用肿瘤杂志》
CAS
北大核心
2011年第2期207-210,共4页
Journal of Practical Oncology
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