IL-17的信号传导及功能研究

IL-17 Signaling and Function

白介素17(IL-17),辅助性T细胞T_H17分泌的特征性细胞因子,在抵抗胞外细菌、真菌感染的宿主防御以及各种自身免疫性疾病发病中起到了重要的作用。本文对T_B17细胞、IL-17的发现作了历史性回顾,并综述了IL-17受体介导的信号传导途径和生理功能的研究进展,为T_H17细胞、IL-17及其受体作为药物治疗的新靶点提供新思路。

Interleukin-17 （IL-17）, the signature cytokine secreted by T helper 17 cells（TH 17）, plays important roles in host defense against extracellular bacterial infection and fungal infection and contributes to the pathogenesis of various autoimmune diseases. Here we reviewed the histological discovery of TH17 and IL-17, and recent advances in IL-17-mediated signaling and its functions in physiology and pathology, providing perspective on potential drug targets for the treatment of autoimmune diseases.