Notch信号通路对干细胞分化的影响

The Effect of Notch Signal Pathway on Stem Cell Differentiation

干细胞的增殖分化受到自身或外在、远程或近程多种信号通路的调控,而细胞之间的相互通讯在此过程中起到重要作用。Notch通路就是通过相邻细胞之间相互通讯调控细胞分化的重要信号通路之一,众多研究显示,该通路的活化在干细胞分化过程中发挥了重要调节作用,本文就此相关研究进展作一简要综述。

The proliferation and differentiation of stem cells are regulated by a variety of signaling pathways （internal or external, and local or distance）, and the communications between cells play an important role in this process. Notch pathway is just one of the important molecules which regulate cell differentiation via the communications between adjacent cells. Through great quantity of research, the important regulatory role of activating this pathway in the process of stern cell differentiation is confirmed. All progresses concerning this researching will be reviewed in the present paper.