莫达非尼对48h睡眠剥夺条件下健康志愿者体温、心率和呼吸频率的影响

Effects of Modafinil on Temperature,Heart Rate and Respiration Rate of Healthy Volunteers during 48 h Sleep Deprivation

目的观察48 h睡眠剥夺条件下服用莫达非尼对受试者体温、心率和呼吸频率的影响。方法 6名健康男性青年志愿者,进行2次48 h睡眠剥夺(间隔2周)。实验从第1天7:00持续到第3天7:00,分别于实验第2天0:00,16:00和第3天0:00交叉服用莫达非尼和安慰剂,每次200 mg。记录基础值(第1天9:00)及每次服药后1 h,3 h,5 h,7 h的体温、心率和呼吸频率数据,并进行统计学分析。结果与基础值相比,睡眠剥夺后体温和心率明显降低,呼吸频率变化不明显。与安慰剂同时刻相比,服用莫达非尼后,体温在睡眠剥夺第2天的23:00(P<0.01),第3天的1:00(P<0.05),3:00(P<0.01)和5:00(P<0.05)明显升高;心率在睡眠剥夺第2天19:00(P<0.01),23:00(P<0.05),第3天1:00(P<0.05),3:00(P<0.01),5:00(P<0.01)和7:00(P<0.05)明显增加。结论服用莫达非尼可明显上调受试者48 h睡眠剥夺后的体温和心率波动曲线。

Objective To investigate the effects of modafinil on temperature,heart rate（HR） and respiration rate of subjects during 48 h sleep deprivation（SD）.Methods Six male healthy volunteers experienced two periods of 48 h continuous wakefulness during a crossover trail separated by 2 weeks.Modafinil（200 mg） or placebo was administered at 0：00,16：00 on the 2nd day and at 0：00 on the 3rd day in the trail respectively.Temperature,HR and respiration were recorded before SD as fundamental data and at 1 h,3 h,5 h and 7 h after drug administration.Data were analyzed with statistic method.Results Compared with fundament,temperature and heart rate decreased following SD but respiration rate did not change significantly.Compared with the placebo,body temperature of modafinil group rose at 23：00（P0.01） on the 2nd day,1：00（P0.05）,3：00（P0.01） and 5：00（P0.05） on the 3rd day during SD;heart rate of modafinil group increased at 19：00（P0.01）,23：00（P0.05） on the 2nd day,and at 1：00（P0.05）,3：00（P0.01）,5：00（P0.01）,7：00（P0.05） on the 3rd day during SD.Conclusion Modafinil can regulate body temperature curve and heart rate curve of volunteers upwardly during 48 h SD.