CD4^+CD25^+调节性T细胞在变应性鼻炎患者外周血淋巴细胞中的含量研究

Content of CD4^+CD25^+ regulatory T cells in peripheral blood lymphocytes in patients with allergic rhinitis

目的:研究CD4+CD25+调节性T细胞(CD4+CD25+Treg)在变应性鼻炎外周血淋巴细胞中的比例,并探讨其临床意义。方法:采用流式细胞术分别检测20例季节性变应性鼻炎患者发作期外周血CD4+CD25+Treg在淋巴细胞中的比例,并与8例健康对照者进行比较。结果:变应性鼻炎患者外周血CD4+CD25+Treg和CD4+CD25highTreg所占比例与对照组比较差异均有统计学意义(均P<0.05)。结论:变应性鼻炎患者外周血CD4+CD25+Treg在外周血中的比例明显减少,可能与该病的发病机制有关。

Objective：To investigate the change of CD4＋CD25＋regulatory T cells（Tregs） of peripheral blood in allergic rhinitis（AR） patients.Method：T lymphocytes of twenty AR patients and eight healthy subjects were separated and the flow cytometry was used to measure the percentage of CD4＋CD25＋Treg.Result：Compared with control group,the percentage of Treg and CD4＋CD25high Tregs of AR patients was decreased significantly（P0.05）.Conclusion：The proportion of CD4＋CD25＋Tregs decreased in AR patients conspicuously,which might be one of the pathogenesis of AR.