丹参和生脉注射液对腹腔感染并SIRS患者血清MDA和SOD的影响

Salvia Miltiorrhiza and Shengmai injection in the treatment of SIRS caused by abdominal infection,and the effect on oxygen free radicals

目的探讨治疗腹腔感染SIRS时加用丹参和生脉注射液对氧自由基的影响。方法将50例腹腔感染致SIRS患者随机分为对照组(常规现代医学综合治疗)及观察组(常规现代医学综合治疗加用中药丹参和生脉注射液)。动态观察体温、白细胞计数及血清丙二醛(MDA)、超氧化物歧化酶(SOD)水平。结果观察组第2,4天血MDA较对照组明显降低,而SOD水平较对照组显著升高;体温、白细胞计数下降亦快于对照组。结论在常规现代医学综合治疗基础上,加用中药丹参和生脉注射液能降低损害因子MDA,升高保护因子SOD,阻止全身炎症反应升级,对治疗SIRS有增强作用。

Objective To evaluate the influences on oxygen free radicals of SIRS due to abdominal infection treated by Salvia Miltiorrhiza and Shengmai injection. Methods Fifty patients with SIRS due to abdominal infection were divided into 2 groups：Group A,treated by combined western medicine（n=25）;Group B,treated by combined western medicine plus Salvia Miltiorrhiza and Shengmai injection（n=25）.Plasma malondialdehyde（MDA） and Superoxide dismutase（SOD） were measured before treatment and on day 2 and day 4 after treatment. Results The serum levels of MDA in group B decreased more rapidly than those in group A,and the serum levels of SOD in group B increased more rapidly than those in group A. Conclusions On the basis of combined western medicine treatment,addition of Salvia Miltiorrhiza and Shengmai injection has therapeutic effect on SIRS by decreasing the harmful MDA factor and increasing the defensive SOD factors,and thereby can alleviate inflammatory injury and prevent further MODS.