肿瘤的免疫逃逸机制研究进展

The progresses of tumor escape mechanism

大量研究证实,肿瘤病人体内存在广泛的免疫逃避现象。目前所知的肿瘤逃逸机制很多,比如产生免疫抑制因子,改变表面抗原,通过Fas/Fasl反击机体的免疫系统而逃避机体的免疫监视,从而发生免疫逃逸。本文就肿瘤发生免疫逃逸机制的研究现状作一综述。

The fact that the immune response to cancer is compromised has been convincingly demonstrated in cancer patients.There are many mechanisms of tumors escape,for example,the tumors can escape immunosurveillance through producing immunosuppressive factors,changing their surface antigens,and utilizing Fas/Fasl.In this article,we summarize the mechanisms by which how the escape happens.