谷酰胺在新生大鼠高氧肺损伤中的作用及其机制初探

Glutamine to damage in newborn big mouse Gao Yangfei the function and at the beginning of the mechanism searches

目的：探讨谷酰胺在新生大鼠高氧肺损伤中的作用及其可能机制。方法：本文比较研究了空气组、谷酰胺组、高氧组等三组新生大鼠的实验开始后第3、6d的存活率和体重，比较实验开始后第6d的右肺湿重／干重及热休克蛋白70（heatshockpro—tein70，HSP70）的表达情况。结果：谷酰胺的预防性使用明显改善了高氧肺损伤时新生大鼠的生存率，有利于新生大鼠的生长发育；另外，预防性使用亦增加了高氧肺损伤时新生大鼠肺组织HSP一70的表达。结论：谷酰胺可以有效地保护新生大鼠高氧肺损伤，而其作用机制可能与HSP-70有关。

Objective：To investigate the effect and mechanism of glutamine in protect hyperoxia--induced lung injury of neonatal rats. Methods： This article compared the 3,6 d survival rate and weight in air group,glutamine group, and high--oxygen group. It also compared the lung wet weight / dry weight and heat shock protein 70（heat shock protein70, HSP70）expression in the first 6d of experimental. Results： The prophylactic use of glutamine significantly improved the high oxygen lung injury survival rate of newborn rats, and it is conducive to the growth of newborn rats. In addition,lung tissue HSP--70 expression level of the newborn rats was also increased by using glutamine. Con- dusions ： Glutamine can effectively protect the high oxygen lung in] ury in neonatal rats, and its mechanism may be related with the HSP--70