热休克蛋白与支气管哮喘

Heat shock proteins and bronchial asthma

热休克蛋白是从细菌到人类均广泛存在的一类热应急蛋白质,并且广泛参与了机体的免疫调节过程。支气管哮喘(简称哮喘)是一种气道慢性炎症性疾病,亦被认为是一种自身免疫性疾病,其发病率逐年上升,已成为全球普遍关注、严重危害公众健康的常见病。目前,细胞免疫功能紊乱被视为哮喘的重要发病机制。越来越多的证据表明,热休克蛋白极可能参与哮喘的发病过程。

Heat shock proteins are a series of widespread proteins due to heat stress from bacteria to human,which are broadly participate in the process of immune regulation.Bronchial asthma（asthma）is a chronic airway inflammatory disease,which is also considered an autoimmune disease.With asthmatic incidence increased year by year,it causes a global common concern and become a common disease that is seriously danger to public health.Nowadays,the cellular immune dysfunction is considered important to the pathogenesis of asthma.There is growing evidence that heat shock proteins are likely involved in the pathogenesis of asthma.