吸烟对大隐静脉旁路血管张力的影响

Effect of smoking on great saphenous vein tone

目的 探讨吸烟对大隐静脉旁路血管张力的影响.方法 选取吸烟10年以上（A组,12例）、戒烟1年以上（B组,9例）、不吸烟（C组,10例）行冠状动脉旁路移植术病人,每例术中留取其1 cm长大隐静脉旁路血管,修剪成3条3 mm宽血管环.采用器官管槽法,在37℃有氧条件下,观察比较各组血管环在不同浓度（10-9～10-5mmol/L）的苯肾上腺素作用下的血管收缩反应,及待10-5mmol/L苯肾上腺素收缩达到一定平台后,不同浓度乙酰胆碱（10-9～10-5 mmol/L）和硝酸甘油（10-9～10-4mmol/L）引发的血管舒张反应.结果 苯肾上腺素引发的血管收缩反应及硝酸甘油引发的血管舒张反应在三组之间差异无统计学意义;乙酰胆碱引发的血管舒张反应,A组明显低于B组与C组,但B组与C组两组差异无统计学意义.结论 长期吸烟对大隐静脉旁路血管内皮依赖性舒张有抑制作用,戒烟1年以上有利于恢复因长期吸烟所抑制的内皮依赖性舒张功能.

Objective To observe the effect of smoking on the great saphenous vein tension. Methods The rings of great saphenous vein in 3mm long of selected from 31 patients with coronary artery bypass grafting were divided into three groups ：smoking over 10 years（ group A, n = 12 ）, ex-smoking over 1 years （ group B, n =9 ） and non-smoking（ group C, n =10）. The changes of the tone were measured in organ chamber at 37℃ with a constant supply of oxygen when vasoconstriction induced by phenylephrine （ 10 -9 - 10 -5 mmol/L）, and vasodilatation by acetylcholine （ 10 -9 - 10 -5 mmol/L） or nitroglycerin（ 10 -9 - 10 -4 mmol/L）after the rings were precontracted by 10 -5 mmol/L phenylephrine. Results Vasoconstriction induced by phenylephrine and vasodilatation by nitroglycerin is no significant difference among three groups. Compared with group A, vasodilatation by acetylcholine was significantly increased in group B or C, while there is no significant difference between group B and C. Conclusion Smoking has a deleterious effect on the endothelial function of great saphenous vein, however, smoking cessation over 1 year may help to restore the endothelial function impaired by smoking.