β-catenin与VEGF-C和-D在结直肠癌中的表达及其相关性

Expression of β-catenin and VEGF-C/-D in colorectal cancer

目的:探讨结直肠癌β-连环素(β-catenin)与血管内皮生长因子-C和-D(VEGF-C,VEGF-D)的表达相关性及其意义.方法:应用免疫组织化学SP法检测96例结直肠癌及正常结直肠组织中β-catenin与VEGF-C和-D的表达,并分析其相关性和意义.结果:正常结直肠黏膜β-catenin细胞膜阳性表达,结直肠癌β-catenin主要呈细胞核和/或细胞质异位表达,异位表达率为67.70%;结直肠癌组织VEGF-C和-D阳性率明显高于正常结直肠组织(43.75%vs19.79%;38.54%vs13.54%,均P<0.01);而且β-catenin与VEGF-C和-D的表达呈显著正相关(均P<0.01).结论:结直肠癌β-catenin异位表达可能是VEGF-C和-D高表达的重要原因,其在结直肠癌淋巴管生成中可能起重要作用.

AIM：To investigate the expression of β-catenin and vascular endothelial growth factor-C/-D（VEGF-C/-D） in colorectal cancer（CRC） and to analyze their significance.METHODS：The expression of β-catenin and VEGF-C/-D in 96 CRC specimens were detected by immunohistochemistry.RESULTS：In normal colonic mucosa,β-catenin was detected on the plasma membrane of epithelial cells.Reduced membrane expression of β-catenin was noted in CRC,and 67.71% of cases of CRC showed cytoplasmic and nuclear expression of β-catenin.The positive rates of VEGF-C/-D expression were significantly higher in tumor tissue than in normal mucosa（43.75% vs 19.79%;38.54% vs 13.54%,both P 0.01）.The expression of β-catenin had a significantly positive correlation with that of VEGF-C/-D（both P 0.01）.CONCLUSION：Cytoplasmic and nuclear β-catenin expression may induce VEGF-C/-D overexpression in CRC,which may play an important role in lymphangiogenesis in CRC.