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高血压合并左心室肥厚患者血清白细胞介素18的变化 被引量：3

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摘要 目的观察高血压合并左心室肥厚(LVH)患者血清白细胞介素18(IL-18)的变化。方法入选初诊单纯原发性高血压患者(66例)、高血压合并LVH患者(56例)和同期健康体检者(对照组,50例)为研究对象,采用双抗体夹心酶联免疫吸附法检测各研究对象血清IL-18的水平,比较各组间的差异。结果与对照组比较,单纯高血压组和高血压合并LVH组患者血清IL-18水平升高(均P<0.05),高血压合并LVH组患者血清IL-18水平又高于单纯高血压组(P<0.05)。高血压患者左心室质量指数(LVMI)和血清IL-18水平随着血压水平的上升而升高(P<0.05)。高血压患者血清IL-18水平与LVMI呈正相关(r=0.575,P<0.01)。多元逐步回归分析发现血清IL-18浓度与LVMI呈正相关(β=0.19,t=5.52,P<0.01)。结论高血压患者血清IL-18水平明显高于正常人群,高血压合并LVH患者血清IL-18水平进一步升高。
作者 王喜梅 雷光明 张新萍 胡曙云
机构地区 鹤壁职业技术学院医学院 河南省鹤煤总医院
出处 《中华高血压杂志》 CAS CSCD 北大核心 2011年第3期286-288,共3页 Chinese Journal of Hypertension
关键词 白细胞介素18 高血压 左心室肥厚
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献10

  • 1刘力生,王文,姚崇华.中国高血压防治指南(2009年基层版)[J].中华高血压杂志,2010,18(1):11-30. 被引量：861
  • 2Vermot-Desroches C, Subiger O, Guenot F, et al. Monoclonal antibodies specific for the IL-18 receptor[J]. Cell Immunol, 2005, 236(1/2) : 101-104.
  • 3Chandrasekar B, Mummidi S, Claycomb WC, et al. Interleukin- 18 is a prohypertrophic cytokine that acts through a phosphati- dylinositol-3-kinase-phosphoinositide-dependent kinase-1-Akt- GATA4 signaling pathway in cardiomyocytes[J]. J Biol Chem, 2005,280(6) :4553-4567.
  • 4Rosario RF, Wesson DF. Primary hypertension and nephropathy [J]. Curr Opin Nypertens, 2006,15(2) : 130-134.
  • 5Cottone S, Mule G, Nardi E, etal. Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension[J]. Am J Hypertens,2006,19(3) ,313-318.
  • 6Bautista LE, Vera LM, Arenas IA, et al. Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-alpha) and essential hypertension[J]. J Hum Hypertens, 2005,19(2) : 149-154.
  • 7Sesso HD, Buring JE, Rifai N, et al. C-reative protein and the risk of developing hypertension[J]. JAMA, 2003,290(22) : 2945-2951.
  • 8辛颖(综述),宋晓东,惠汝太(审校).左心室肥厚的影响因素及机制的研究进展[J].中国分子心脏病学杂志,2009,9(1):56-59. 被引量：15
  • 9Woldbaek PR, Tommessen T, Henriksen UL, et al. Increased cardiac IL-18 mRNA, pro-IL-18 and plasma IL-18 after myocardial infarction in the mouse: a potential role in cardiac dysfunction [J]. Cardiovasc Res,2003,59(1) : 122-131.
  • 10Blankenberg S, Luc G, Ducimetiere P, et al. Interleukin-18 and the risk of coronary heart disease in Europeanmen: the prospective epidmiological study of myocardial infarction(PRME)[J]. Circulation, 2003,108 (20): 2453-2459.

二级参考文献30

  • 1Lorell BH,Carabello BA.Left ventricular hypertrophy:pathogenesis,detection,and prognosis.Circulation,2000,102:470-479.
  • 2Wollert KC,Drexler H.Regulation of cardiac remodeling by nitric oxide:focus on cardiac myocite hypertrophy and apaptosis.Heart Fail Rev,2002,7:317-325.
  • 3Kempf T,Wollert KC.Nitric oxide and the enigma of cardiac hypertrophy.Bioessays,2004,6:608-615.
  • 4Russell B,Motlagh D,Ashley WW.Form follows function:how muscle shape is regulated by work.J Appl Physiol,2000,88:1127-1132.
  • 5Ozaki M,Kawashirna S,Yamashita T,Hirase T,Ohashi Y,Inone N,et al.Overexpression of endothelial nitric oxide synthase attenuates cardiac hypertrophy induced by chronic isoproterenol infusion.Circ J,2002,66:851-856.
  • 6Von Harsdorf R,Kang RE,Fullerton M,Woodcock EA.Myocardial stretch stimulates phoephatidyl-inositol turnover.Circ Res,1989,65:494-501.
  • 7Sussman A,Mcculloch A,Borg TK.Dance band on the titanic:biomechanical signaling in cardiac hypertrophy.Cire Res,2002,91:888-898.
  • 8Burridge K,Chrzanowska-Wodnicka M.Focal adhesions,contractility,and signaling.Anna Rev Cell Dev Biol,1996,12:463-519.
  • 9Campos LA,lliescu 8,Fontes M,Sehlegel WP,Bader M,Baltstu OC.Enhanced isoproterenol-induced cardiac hypertrophy in transgenic rats with low brain angiotensinogen.Am J Physiol Heart Cite Physiol,2006,291 (5):H2371-2376.
  • 10Shubeita HE,Martinson EA,Van Bilsen M,Chien KB,Brow JHTranacriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventriculac myocytes.Proc Natl Acad Sci USA,1992,89:1305-1309.

共引文献874

同被引文献42

  • 1刘力生.中国高血压防治指南2010[J].中国医学前沿杂志（电子版）,2011,3(5):42-93. 被引量：1227
  • 2孙莉,高月红,田登科,郑建普,朱春赟,可燕,卞卡.自发性高血压大鼠多组织炎症状态(英文)[J].生理学报,2006,58(4):318-323. 被引量：18
  • 3张亚文,丁茹,吴宗贵,陈琴珍,王丽娟.奥美沙坦酯治疗轻中度原发性高血压的疗效和安全性[J].世界临床药物,2006,27(10):585-589. 被引量：9
  • 4Wang M, Markel TA, Meldrum DR. Interleukin 18 in the heart [ J]. Shock,2008 ; 30( 1 ) :3-10.
  • 5Chandrasekar B, Mummidi S, Claycomb WC, et al. Interleukin-18 is a pro-hytrtrophic cytokine that acts through a phosphatidylinosi- tol 3-kinase- naling pathway in cardiomyocytes [ J kinase-1 -Akt-GATA4 sig- J Biol Chem, 2005,280(6) :4553-4567.
  • 6Majumdar G, Rooney RJ, Johnson IM, et al. Panhistone deacety- lase inhibitors inhibit proinflammatory signaling pathways to amelio- rate interleukin-18-induced cardiac hypertrophy [ J]. Physiol Ge- nomics, 2011,43 (24) : 1319-1333.
  • 7Colston JT, Boylston WH, Feldman MD, et al. Interleukin-18 knockout mice display maladaptive cardiac hypertrophy in response to pressure overload [ J ]. Biochem Biophys Res Commun, 2007, 354(2) : 552-558.
  • 8Platis A, Yu Q, Moore D, et al. The effect of daily administration of IL-18 on cardiac structure and function [ J ]. Perfusion, 2008, 23(4) :237-242.
  • 9Miura S. Do all angiotensin 1I type 1 receptor blockers have the same benefici effects[ J]. Br J Pharmacol, 2007,151 (7) :912- 913.
  • 10Mancia G, Laurent S, Agabiti-Rosei E, et al. Reappraisal of Euro- pean guidelines on hypertension management : a European Society of Hypertension Task Force document [ J ]. J Hypertens ,2009,27 (6) :2121-2158.

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二级引证文献11

中华高血压杂志
2011年 第3期

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