IL-18通过MyD88依赖信号途径调控CSF-1表达(英文)

IL-18 Stimulates CSF-1 Expression via MyD88-dependent Pathway

IL-18是IL-1家族的一个成员,最初发现被命名为IFN-γ诱导因子.现在研究表明,IL-18是炎症反应的重要标志,参与许多慢性炎症和自身免疫性疾病炎性反应.证明了IL-18在JurkatT淋巴细胞的炎症反应中能够调节CSF-1的表达,其信号机制是IL-18通过MyD88-NF-κB-CSF-1信号途径上调CSF-1的基因转录.

Interleukin-18（IL-18） is a new member of IL-1 cytokine family and known as IFN-γ-inducing factor previously.An increased secretion of IL-18 is generally a marker for many chronic inflammation and autoimmune disorders,implying its involvement in inflammatory responses.Here,it was showed that IL-18 stimulated the expression of CSF-1 in Jurkat T lymphocytes that might be a manifestation for IL-18 to play its biological functions in inflammatory pathogenesis.The signaling mechanism that contributes to IL-18-induced transcriptional activation of CSF-1 was investigated further.Combined data suggested a MyD88-NF-κB-CSF-1 signal pathway is involved in the up-regulated expression of CSF-1.