干细胞移植治疗肝硬化顽固性腹水的疗效观察

Clinical observation of hepatic stem cell transplantation on cirrhosis with refractory ascites

目的观察干细胞移植治疗肝硬化顽固性腹水的疗效。方法 39例肝硬化顽固性腹水患者分为对照组16例,行常规治疗;治疗组23例,在常规治疗基础上行干细胞移植。比较两组患者移植前与移植后临床症状、腹水持续正常时间、肝肾功能及健康状况量化评分变化。结果两组在治疗后3个月腹水均有一定程度缓解,治疗组干细胞移植患者腹水增长速度放缓;治疗组白蛋白合成及肾功能的好转均优于对照组(P<0.05),胆碱酯酶和凝血酶原活动度变化不明显(P>0.05);根据KPS评分,两组健康状况均较治疗前好转(P<0.05),治疗组健康状况好转优于对照组(P<0.05)。结论干细胞移植治疗肝硬化顽固性腹水有较好近期疗效,其价格低廉、技术风险小,可进一步推广使用。

Objective To observe the clinical effect of hepatic stem cell transplantation on cirrhosis with refractory ascites. MethodsThirty-nine cases of cirrhosis patients with refractory ascites were divided into control group（16 cases）and treatment group（23 cases）.Control group was given conventional treatment,treatment group was given stem cell transplantation upstream in the conventional therapy.The clinical symptoms,time of ascites continued to normal,liver and kidney function and health status score were detected before and after treatment in two groups. ResultsThe ascites had a certain degree of relief after treatment.The increment speed of ascites slowed down after stem cell transplantation.The synthesis of albumin and renal function were better in the treatment group than those in control group（P0.05）,but cholinesterase and prothrombin activity were not significantly changed（P0.05）;according to KPS,the healthy status of two groups were better after treatment（P0.05）.Healthy status of treatment group was better than that of control group（P0.05）. ConclusionThe clinical effect of stem cell transplantation for liver cirrhosis with refractory ascites has a good short-term effect.It is worth further using because of low prices and technical risk.