高脂血症、微循环障碍与急性胰腺炎关系的探讨

Relationship of hyperlipemia,microcirculation with acute pancreatitis

目的探讨高脂血症(特别是高三酰甘油血症)、微循环障碍与急性胰腺炎严重度的关系,加强对高脂血症性急性胰腺炎(hyperlpidemic acute pancreatitis,HLAP)的认识。方法将我院2006年1月～2009年8月收治的143例急性胰腺炎患者,按临床表现分为轻型急性胰腺炎(mild acute pancreatitis,MAP)82例,占57.34%,重症急性胰腺炎(severe acute pancreatitis,SAP)61例,占42.66%;按病因分为脂源性胰腺炎(hyperlipemia acute pancreatitis,HLAP)42例,占29.37%,非脂源性胰腺炎(non-hyperlipemia a-cute pancreatitis)101例,占70.63%。探讨高脂血症与MAP和SAP的关系。结果脂源性胰腺炎与非脂源性胰腺炎组比较,全血黏度(高切)、全血黏度(低切)、CRP差异有统计学意义(P<0.001),脂源性胰腺炎组并发症发生率较高且严重。结论故高三酰甘油(TG)血症、微循环障碍是AP持续和加剧损害的因素。

Objective To investigate the relationship of hyperlipemia,microcirculation with the severity of acute pancreatitis（SAP）,and enhance the knowledge about hyperlipidemic acute pancreatitis（HLAP）. MethodsOne hundred and forty-three cases of AP patients hospitalized in our hospital from January,2006 to August,2009 were collected.According to clinical manifestation,they were divided into mild acute pancreatitis（MAP,82 cases） group and severe acute pancreatitis（SAP,61 cases） group.According to etiopathogenisis,they were divided into hyperlipemia（42 cases） group and non-hyperlipemia（101 cases） group.The relationship of hyperlipemia with MAP and SAP was discussed.Results Compared with non-hyperlipemia group,the hyperlipemia group had higher mobidity of complications and severer complications,with whole blood viscosity（high shear）,whole blood viscosity（low shear） and CRP（P0.001）. Conclusion Hypertriglyceridemia,microcirculation are the factors that cause AP to continue and aggreviate.