脑源性神经营养因子对肠道感觉调节作用的研究

Regulating effect of brain-derived neurotrophic factor in the sensitivity of intestinal tract

脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)不仅作为一种神经营养物质,对神经元发育及功能维持发挥重要作用,而且作为一种神经递质,对神经元的功能发挥了重要的调节作用。BDNF在中枢的感觉调节作用已被大量研究,证实BDNF有致痛及致敏感性作用。肠道系统大量表达BDNF及其受体,提示BDNF可能通过与对中枢感觉调节相似的机制来调节肠道的感觉。近期许多学者在此方面也做了一些研究,本文就脑源性神经营养因子对肠道感觉的调节作用及分子机制的研究做一综述。

Brain-derived neurotrophic factor（BDNF） not only plays fundamental roles in the differentiation,survival and maintenance of neurons as a member of the nerve growth factor family,but also plays an important role in modulation of neurons as a kind of neurotransmitters.A lot of researches about the role of BDNF in modulating the sensation in CNS have proven that BDNF is an important factor in chronic pain and visceral sensitivity.In intestinal tract,abundance of BDNF and its receptor protein were found,implying that the mechanism of BDNF modulating sensitivity in intestinal tract is similar in CNS.Recently,some researches were carried out in this field.This article is to summarize the researches about the regulating effect and molecular mechanism of BDNF in the sensitivity of intestinal tract.