降气和胃通腑法对肠癌患者术后胃肠功能及免疫功能的影响

Use of Jiangqi Hewei Tongfu method to improve gastrointestinal function and immune function in patients with intestinal tumors after surgery

目的:观察针灸和中药恢复肠癌术后患者胃肠功能和免疫功能的临床疗效.方法:将肠癌根治性手术后的105例患者随机分成对照组、中药组和针灸组,各35例.对照组给予术后常规处理;中药组给予术后常规处理和术后第1天营养管推入四磨汤口服液20mL,每日3次,治疗10d;针灸组给予术后常规处理和术后第1天针灸治疗,每日1次,治疗10d.结果:3组术后肠功能恢复比较,差异有统计学意义(F=18.98,P<0.05),针灸组与中药组、对照组比较,差异有统计学意义(P<0.05,P<0.01),中药组与对照组比较,差异无统计学意义(t=0.429,P>0.05).针灸组在术后外周血白细胞计数、淋巴细胞计数及中性粒细胞计数变化方面优于中药组、对照组,差异有统计学意义(P<0.05或<0.01).针灸组在改善术后T淋巴细胞亚群及NK细胞变化方面优于中药组和对照组,差异有统计学意义(CD3:69.44%±6.37%vs57.62%±8.08%,56.57%±8.90%,F=31.25;CD4:35.63%±6.26%vs30.28%±6.66%,30.89%±6.25%,F=7.42;CD4/CD8:1.27%±0.44%vs1.01%±0.45%,1.03%±0.64%,F=5.64;NK:13.29%±3.45%vs11.88%±3.89%,10.64%±2.64%,χ2=10.39,均P<0.05).临床症状改善方面3组比较,差异有统计学意义(F=5.75,P=0.004),针灸组优于中药组和对照组(均P<0.05).ZPS评分比较,差异有统计学意义(F=13.85,P=0.00),针灸组优于中药组和对照组(均P<0.05).结论:降气和胃通腑法对恢复肠癌术后患者胃肠功能及免疫功能有较好的疗效,而且可以调节外周血白细胞、淋巴细胞和中性粒细胞值,改善患者临床症状,以针灸组效果最好.

AIM：To observe the clinical effect of acupuncture and traditional Chinese medicine in improving the gastrointestinal function and immune function in patients with intestinal tumors after surgery.METHODS：One hundred and five patients were randomly and equally divided into three groups：control group,Chinese medicine group,and acupuncture group.The control group received only conventional therapy,while the Chinese medicine group underwent conventional ther-apy and treatment with Simotang Oral Liquid（three times daily for 10 d）,and the acupuncture group underwent conventional therapy and acupuncture（once a day for 10 d）.RESULTS：On day 10 after treatment,the recovery of gastrointestinal function was signif icantly different among the three groups（F = 18.98,P 0.05）.Compared with the control group and traditional Chinese medicine group,the acupuncture group showed more rapid recovery of gastrointestinal function（both P 0.05）.Compared with the control group and traditional Chinese medicine group,the counts of leukocytes,lymphocytes and neutrophils were signif icantly improved in the acupuncture group（all P 0.05）.The percentages of CD3,CD4,CD4/CD8 and NK cells differed significantly among the three groups（CD3：69.44% ± 6.37% vs 57.62% ± 8.08%,56.57% ± 8.90%,F = 31.25;CD4：35.63% ± 6.26% vs 30.28% ± 6.66%,30.89% ± 6.25%,F = 7.42;CD4/CD8：1.27% ± 0.44% vs 1.01% ± 0.45%,1.03% ± 0.64%,F = 5.64;NK：13.29% ± 3.45% vs 11.88% ± 3.89%,10.64% ± 2.64%,χ2 = 10.39,all P 0.05）.The score of digestive system symptoms and ZPS were also significantly different among the three groups（all P 0.05）.CONCLUSION：Jiangqi Hewei Tongfu method can promote the recovery of gastrointestinal function and immune function,bidirectionally modulate the numbers of leukocytes,lymphocytes and neutrophils,and thereby improve the score of digestive system symptoms and ZPS in patients with intestinal tumor after surgery.