飞行时间质谱仪监测甲基丙烯酸甲酯释放初探

Monitoring of methyl methacrylate monomer released from autopolymerized denture base polymers during processing using time-of-flight mass spectrometer

目的 通过飞行时间质谱仪对自凝树脂聚合反应的全过程进行连续监测,动态分析甲基丙烯酸甲酯（methyl methacrylate,MMA）的变化趋势,以期为临床操作提供指导.方法 按生产厂家要求的比例将自凝义齿基托树脂粉剂2 g和液剂1 g调拌40 s后,即刻用飞行时间质谱仪连续监测MMA释放量,共监测5个样本.结果 MMA释放量在调拌后11 min时快速增加[（45.2±3.5）mg/L],13 min时达高峰[（228.9±22.6）mg/L];23 min时趋于稳定[（8.8±2.3）mg/L].结论 飞行时间质谱仪可连续监测自凝义齿基托树脂的聚合过程,精确地分析MMA释放量的变化趋势.结果 显示自凝义齿基托树脂聚合反应的MMA释放量变化较快.

Objective To analyze the amount and tendency of methyl methacrylate（MMA） released from autopolymerized denture base polymer （self-curing resin） during processing using time-of-flight mass spectrometer（TOF-MS）. Methods Self-curing resin was mixed in the container using a ratio of 2 g of powder to 1 g of liquid in accordance with the manufacturer＇s instructions for 40 s as a specimen. The amount of MMA released from the specimen was continuously monitored and simultaneously recorded every minute by TOF-MS since immediately after mixing. A total of five specimens were monitored. Results The amount of MMA increased dramatically at 11 min[（45.2 ±3.5） mg/L] after mixing, and reached the highest level at 13 min[（228.9 ±22.6） mg/L], then become stable at 23 min[（8.8 ±2. 3） mg/L] after mixing. Conclusions The releasing tendency of MMA could be analyzed accurately with continuously monitoring during processing. The amount of MMA released from self-curing resin changed rapidly and the processing was complicated and changeful.