摘要
合成2.0G聚酰胺-胺(PAMAM)并进行端基甲基丙烯酰基修饰,将最外层接枝光化学活性双键,修饰产物(PAMAM-DB)与甲基丙烯酸酐化癸二酸(MSA)用二甲基亚砜(DMSO)溶解并在光引发剂存在下,经过紫外光照射得到具有一定生物相容性的凝胶.用1H NMR和FTIR对聚酰胺-甲基丙烯酰胺的结构进行表征.凝胶的降解实验结果表明,聚酸酐(甲基丙烯酸酐化癸二酸)的质量分数为50%~60%的凝胶以表面溶蚀的方式降解,随着聚酸酐在凝胶中含量不同,降解时间在45~60 d之间,pH值在6.5~8.06范围内.包埋氧氟沙星凝胶的降解实验表明,通过改变聚酸酐的含量可以控制降解时间和药物释放量.
2.0G polyamidoamine(PAMAM) were methacylated by methacryloyl chloride and photopolyme-rized with methacrylated sebacic anhydride(MSA) to obtain degradable gels.The structures of polymers were characterized by FTIR and 1H NMR.In order to study the effects of polyamidoamine double bond(PAMAM-DB)∶MSA ratio on the polymer degradation behavior,local pH value,water uptake,mass loss and surface morphology in the course of degradation were explored.It is found that the gels containing mass fraction of 50%—60% anhydride were good surface erosion materials.Degradation time and pH value of degradable medium range from 45 d to 60 d,and from 6.5 to 8.06,respectively.The sample with mass fraction of 50% anhydride was choosed as the bead of ofloxacin based on the degradation experiment.The result shows that the drug-released time and content of drug can be controlled by varing the mass fraction of MSA.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2011年第5期1194-1199,共6页
Chemical Journal of Chinese Universities
基金
湖南省自然科学基金(批准号:06JJ4117)资助
关键词
聚酰胺-甲基丙烯酰胺
聚酸酐
光交联
表面溶蚀
药物控释
Polyamidoamine-methacrylamide
Methacrylated sebacic anhydride(MSA)
Photocrosslink
Surface erosion
Controlled drug release