老年肝硬化患者医院感染特点及相关因素分析

Clinical features and related factors of hospital infections in old patients with hepatic cirrhosis

目的分析老年肝硬化患者医院感染特点并探讨其相关因素。方法对2008年1月-2010年1月,收治的741例肝硬化患者进行临床调查分析。结果有48例老年肝硬化患者发生医院感染,感染率为18.39%,42例非老年肝硬化患者发生医院感染,感染率为8.75%,两组比较差异有统计学意义(P<0.05);感染部位以腹腔感染为主,其次为呼吸道及胃肠道感染,病原菌以革兰阴性杆菌为主;感染的发生与患者年龄、住院时间、基础疾病、上消化道出血、抗菌药物使用及侵入性操作等相关。结论老年肝硬化患者医院感染发生率高,应引起临床重视,采取综合的防治措施,降低肝硬化患者医院感染率,提高老年肝硬化患者的生存质量。

OBJECTIVE To analyze the clinical features and related factors of hospital infection in old patients with hepatic cirrhosis.METHODS The clinical data of 741 hospitalized patients with hepatic cirrhosis were analyzed retrospectively.These patients were enrolled from Jan 2008 to Jan 2010.RESULTS 48 aged patients and 42 non-aged patients with hepatic cirrhosis had hospital infections with the infection rates of 18.39% and 8.75%.The difference was significant（P0.05）.Most infections were abdominal infections,then were respiratory infections and gastrointestinal infections.Most pathogenic bacteria were Gram-negative bacilli.Age,hopitalization time,concomitant disease,upper gastrointestinal bleeding,antibiotics and invasive operations were correlated with hospital infection.CONCLUSION The incidence of hospital infection in old patients with hepatic cirrhosis is high.Comprehensive measures should be adopted to reduce the rate of hospital infection and increase the quality of life in old patients with hepatic cirrhosis.