万古霉素对耐甲氧西林金黄色葡萄球菌的疗效与安全性

Efficacy and safety of vancomycin on methicillin-resistant staphylococcus aureus:a contrast study

目的评价国产去甲万古霉素与进口万古霉素对耐甲氧西林金黄色葡萄球菌(MRSA)的疗效性和安全性。方法 127例MRSA感染患者中69例采用国产盐酸去甲万古霉素,58例采用进口万古霉素,观察细菌学疗效和不良反应。结果国产去甲万古霉素组和进口万古霉素组的细菌清除率分别为82.6%和81.0%,两组比较差异无统计学意义;两组不良反应主要为肾脏毒性和皮疹,发生率分别为7.2%和10.3%,差异无统计学意义。结论国产去甲万古霉素对MRSA敏感性好,临床疗效与进口万古霉素相当,差异无统计学意义。

OBJECTIVE To evaluate the efficacy and safety of demethylvancomycin and vancomycin on methicillin-resistant Staphylococcus aureus（MRSA）.METHODS A total of 69 cases infected with MRSA were treated with demethylvancomycin,and 58 cases were given vancomycin.The bacteriological efficacy and adverse reaction（ADR） were investigated and compared in the two groups.RESULTS The bacterial eradication rates in the two groups were 82.6% and 81.0% respectively with no significance（χ2=0.382,P0.05）.Renal toxicity and rashes were the main ADR with the incidence rates of 7.2% and 10.3%,respectively,and there was no significant difference in the incidence of ADR between the two groups（χ2=0.723,P0.05）.CONCLUSION Demethylvancomycin has good sensitivity to MRSA.Its clinical efficacy is the same as vancomycin,and has lower incidence of ADR.