血清联合检测在肝癌中的诊断价值

Clinical value of combined detection of serum AFP,CEA,CA19-9 in diagnosis of liver cancer

目的探讨血清甲胎蛋白(AFP)、癌胚抗原(CEA)、肿瘤标志物(CA19-9)联合检测在肝癌中的诊断价值。方法 2008年1月-2009年1月住院的肝癌患者36例,另选30例肝硬化患者及同期在医院内体检的健康者32例作对照,检测3组的血清AFP、CEA、CA19-9水平。结果肝癌组AFP、CEA、CA19-9水平明显高于肝硬化组和对照组;肝癌组的联合检测阳性率为88.9%,明显高于肝硬化组的46.7%及对照组的6.3%,差异有统计学意义(P<0.05)。结论对肝癌患者进行血清AFP、CEA、CA19-9的联合检测,对于肝癌的早期诊断有重要的临床价值。

OBJECTIVE To investigate the value of serum AFP,CEA,CA19-9 in the combined detection in the diagnosis of liver cancer.METHODS Totally 36 patients with liver cancer,30 patients with cirrhosis and the same period the health physical examination in the hospital,32 healtly patients as controls from Jan 2008 to Jan 2009 in our hospital,were tested for serum AFP test,CEA,CA19-9 level.RESULTS HCC AFP,CEA,CA19-9 levels were significantly higher than the liver cirrhosis group;HCC group,positive rate of combined detection 88.9%,liver cirrhosis group was significantly higher than 46.7% and control group 6.3%,the difference was statistically significant（P0.05）.CONCLUSION To perform the combined detection of serum AFP,CEA and CA19-9 for the liver cancer patients has important clinical value in early diagnosis of liver cancer.