血清HE4在卵巢癌中的表达及其诊断价值

Expression and predictive value of HE4 level in diagnosis of ovarian carcinoma

目的:探讨测定血清人附睾蛋白4(Human epididymis protein4,HE4)水平对卵巢癌的诊断价值。方法:收集海南医学院附属医院妇科2010年5月～2011年2月收治经病理检查确诊的盆腔肿物患者160例,采用酶联免疫吸附试验方法(ELISA)检测血清HE4和CA125在卵巢癌组、卵巢良性肿瘤组、盆腔其他良性疾病组中的水平,比较各组患者HE4、CA125水平的差异并分析其在卵巢癌诊断中的价值。结果:1.卵巢癌组血清HE4和CA125水平明显高于卵巢良性肿瘤和盆腔其他良性疾病组(P均=0.000),卵巢良性肿瘤组HE4和CA125水平与盆腔其他良性疾病组比较,差异无统计学意义。2.在18例卵巢癌组中,HE4和CA125的阳性率分别为50.00%(9/18)、33.33%(6/18),联合检测HE4和CA125的阳性率为33.33%(6/18)。结论:血清HE4在卵巢癌中高表达,可能有助于卵巢良恶性肿瘤的鉴别诊断。

Objective：To explore the expression and the predictive value of the serum human epididymis protein 4（HE4） level in the diagnosis of ovarian carcinoma.Methods：Data of 160 cases that were diagnosed and confirmed as pelvic mass in our hospital during May 2010 and June 2011 were analyzed,including benign and malignant ovarian tumor and other benign diseases.HE4 and CA125 levels were measured and compared by enzyme-linked immune sorbent assay（ELISA） among these patients.Results：1.HE4 and CA125 levels were significantly higher in patients with ovarian cancer than that in patients with benign tumor or other benign pelvic masses（P=0.000）,but no significant difference was observed between the latter two groups.2.For the 18 malignant ovarian tumor cases,positive rate of serum HE4 and CA125 were 50.00%（9/18）、33.33%（6/18） respectively;positive rate for both serum HE4 and CA125 was 33.33%（6/18）.Conclusions：Serum HE4 level is increased in malignant ovarian tumor thus it＇s helpful for the differentiation of malignant and benign ovarian tumor.