前列地尔联合辛伐他汀治疗颈动脉粥样硬化的临床观察

Effect of alprostadil combined with simvastatin on treatment of carotid atherosclerosis

目的:探讨前列地尔联合辛伐他汀治疗颈动脉粥样硬化(CAS)的临床疗效。方法:将100例CAS患者随机分为治疗组和对照组。对照组给予辛伐他汀治疗,治疗组采用前列地尔联合辛伐他汀治疗,治疗2个月后检测颈动脉内膜中层厚度(IMT)、颈动脉斑块面积、颈总动脉的血流速度及颈总动脉内径的变化。结果:治疗组颈动脉IMT变薄、颈动脉斑块面积缩小,颈总动脉内径增宽、颈总动脉血流速度降低,与对照组比较有显著性差异(P<0.05)。结论:前列地尔联合辛伐他汀治疗CAS,能延缓、逆转CAS进展,增强斑块的稳定性,值得临床推广应用。

Objective：To investigate the effect of alprostadil combined with lipitor on treatment of carotid atherosclerosis（CAS）.Methods：A total of 100 cases with CAS were randomly divided into treatment group and control group.The patients in control group were treated by simvastatin,and the patients in treatment group by alprostadil combined with simvastatin.After 2 months of continuous therapy the carotid intima-media thickness（IMT）,area of carotid artery plaque,blood flow velocity of carotid artery and carotid artery diameter were detected.Results：After treatment the IMT was thinner and the area of carotid artery plaque was reduced in the treatment group compared with the control group,and there was significant difference（P0.05）.The carotid artery diameter was broadened,and blood flow velocity of carotid artery was reduced in the treatment group,with significant difference comparing with control group（P0.05）.Conclusions：The alprostadil combined with simvastatin can delay and reverse the progress of CAS,enhance the stability of atherosclerosis.It is worthy of clinical application.