疏肝健脾汤联合西药治疗慢性胃炎临床观察

Effect of Shuganjianpi decoction combined with western medicine on treatment of chronic gastritis

目的:观察疏肝健脾汤联合西药治疗慢性胃炎的疗效与安全性。方法:将120例慢性胃炎患者随机分入观察组(A组)和对照组(B组和C组),每组40例。所有患者先给予杀菌治疗1周,接下来,A、B、C 3组分别给予疏肝健脾汤+枸橼酸铋钾、疏肝健脾汤+西药安慰剂、枸橼酸铋钾+中药安慰剂治疗4周。观察比较3组临床疗效与不良反应。结果:治疗结束后,观察组(A组)痊愈率(57.5%)高于对照组(B组和C组),差异有统计学意义(χ2=7.11、6.24,P均<0.05);临床症状评分,A组总积分低于B组和C组,差异有统计学意义(t=2.81、2.87,P均<0.01)。不良反应组间差异无统计学意义(χ2=0.46,P>0.05)。结论:疏肝健脾汤联合西药治疗慢性胃炎疗效显著,优于单纯西药或中药治疗,临床使用安全,值得在临床推广应用。

Objective： To observe the clinical efficacy and safety of shuganjianpi decoction com- bined with western medicine in treatment of chronic gastritis. Methods： All 120 patients with chronic gas- tritis were randomly assigned to experimental group（group A） and control groups （group B and group C）. There were 40 cases in each group. At first, All patients were treated with sterilization. Then patients in the group A , B, C were treated with shuganjianpi decoction combined with bismuth potassium citrate, shuganjianpi decoction and the placebo of western medicine, bismuth potassium citrate and the placebo of Chinese medicine, respectively for four weeks. The clinical efficacy and adverse effect of the three groups were observed and compared. Results：In the 5th weekend after treatment, the rate of cure（57.5%） and significant efficiency（85 %） in group A were significantly higher than those in the control groups （group Band C） （x2 =7.11,6.24,all P〈0.05）. The score of clinical symptoms in group A was lower significantly than those in the control groups after treatment（t=2. 81,2. 87,all P〈0.01）. The incidence of adverse effect had no significant difference among the three groups （x2=0.46, P〉0.05）. Conclusions： shuganjianpi decoction combined with western medicine is more effective than western medicine or Chinese medicine alone in treatment of chronic gastritis. It is also safe. Therefore, it is deserved to be spread and ap- plied in the clinic.