FHIT和Livin在非小细胞肺癌中的表达及临床意义

The expression and clinical significance of FHIT protein and Livin protein in non - small cell lung cancer

目的检测FHIT和Livin蛋白在非小细胞肺癌组织中的表达，并对其表达水平与NSCLC临床特征之间的关系进行相关性分析，探讨其与NSCLC的浸润、转移的关系及临床意义。方法采用免疫组织化学sP法检测印例NSCLC组织及19例癌旁正常肺组织中FHIT和Livin蛋白的表达情况，并结合肺癌的临床病理特征进行对比分析。结果FHIT在NSCLC中的阳性表达率显著低于正常肺组织（P〈0．05），Livin在NSCLC中的阳性表达率显著高于正常肺组织（P〈0．05）；FHIT和Livin蛋白表达率均与肺癌的病理类型、细胞分化程度、淋巴结转移、TNM分期密切相关（P〈0．05），而与患者年龄、性别、肿瘤部位及肿块大小无关（P〉0．05）；FHIT与Livin蛋白表达两者呈负相关（P〈0．05）。结论FHIT和Livin蛋白可以作为判断非小细胞肺癌的特异性指标，并为肿瘤基因治疗提供了新的靶点。

Objective To observe expressions of FHIT and Livin in human non - small cell lung cancer （NSCLC） and investigate correlation and clinical significance between FHIT, Livin expression and infiltration, metastasis of NSCLC. Methods The expressions of FHIT and Livin protein in 60 cases of lung cancer and 19 cases of normal lung tissue were detected by SP immunohistochemistry method, and the clinicalpathology features of lung cancer were analyzed statistically. Results Compared with normal lung tissues, there was down - regulation of FHIT expression in NSCLC tissues（ P 〈 0.05 ）, as well as up -regulation of Livin expression in NSCLC tissues（ P 〈 0.05 ）. FHIT and Livin expression had close relationship with pathology type, cell differentiation degree, metas- tasis and TNM staging（ P 〈 0.05）. FHIT and Livin expression had no relationship with patient＇age, sex, tumor location and tumor size （P 〉 0.05）. Conclusion FHIT and Livin expression can be conducted as specific index to NSCLC prognosis. It will provide a new target to tumor gene therapy.