柴胡疏肝散合甘麦大枣汤加减治疗产后抑郁症的临床观察

目的:观察柴胡疏肝散合甘麦大枣汤加减治疗产后抑郁症的临床疗效。方法:将72例符合西医产后抑郁症诊断标准的患者按随机数字表法分为对照组34例和治疗组38例,对照组与治疗组分别应用盐酸氟西汀,柴胡疏肝散合甘麦大枣汤为主方进行随证加减进行干预,疗程为4周,结合汉密顿抑郁量表(HAMD)量化评分的减分率进行疗效评定,并对其进行比较。结果:治疗组在治疗后的HAMD评分、总有效率与对照组比较差异均有统计学意义(P<0.05)。结论:柴胡疏肝散合甘麦大枣汤加减治疗产后抑郁症疗效明显,副作用小。

Objective：To explore the clinical efficacy of Chaihu-Shugan-San Ganmai-Dazao decoction in the treatment of postpartum depression.Methods Seventy-two postpartum depression patients were randomly divided into treatment（n=38）and control group（n=34）,the treatment group was given Chaihu-Shugan-San Ganmai-Dazao decoction for 4 weeks,control group was given Fluoxetine hydrochloride for 4 weeks.Clinical efficacies were assessed with the Hamilton Depression Rating Scale（HAMD）before treatment and at the end of the 2nd and 4th week.Results After treatment the total scores of the HAMD of both groups lowered more significantly compared with pretreatment（P0.01）,but those did more significantly in the treatment than in the control group in the corresponding time period（P0.01）.Conclusion Chaihu-Shugan-San Ganmai-Dazao decoction may notably augment anti-depression effect in the treatment of postpartum depression,higher safety and better compliance.