碳青霉烯类抗生素的研究进展

Pharmacology and Clinical Application of Carbopenems

目的:促进临床对碳青霉烯类抗生素的合理应用。方法:参考国内外文献,对7种碳青霉烯类抗生素的构效特点、药理特点、临床应用等进行阐述,分析比较7个品种之间的不同特点。结果:本类抗生素具有抗菌谱广、抗菌活性强和对β-内酰胺酶高度稳定的特点,经临床验证其疗效确切。结论:碳青霉烯类抗生素是临床治疗严重的混合性感染和对付耐药菌株的有力武器。

Objective：To promote clinical rational use of carbopenems.Methods：With the pertinent literature both home and abroad as reference,the differences among 7 agents of carbopenems were discussed regarding formulation and efficacy,pharmacology,and clinical application.Results：Carbopenems antibiotics were characterized by broad antibacterial spectrum,strong antimicrobial activity and strong stability to β-lactamase,and which showed good efficacy in the clinic.Conclusions：Carbopenems are powerful weapons in the management of mixed infection drug resistant strains.