口服胰岛素治疗青少年功能性消化不良的疗效观察

Efficacy of Oral Insulin in Treatment of Juvenile Functional Dyspepsia

目的探讨胰岛素口服治疗青少年功能性消化不良(FD)的临床疗效和安全性。方法将我院就诊的70例青少年FD患者随机分为对照组和治疗组各35例,对照组给予口服多潘立酮片,治疗组给予口服短效胰岛素0.9U(/kg.d),疗程28d。观察两组临床疗效情况,血糖、血清钾变化,并判定疗效和安全性。结果治疗28d后对照组和治疗组有效率分别为42.9%和88.6%,差异有统计学意义(P<0.01)。两组低血糖发生率、高血糖发生率均为0,治疗后血清钾差异无统计学意义(P>0.05)。结论口服胰岛素辅助治疗青少年FD临床疗效显著,安全性好。

Objective To investigate the clinical efficacy and safety of oral insulin for treatment of juvenile functional dyspepsia （FD）. Methods In this pilot randomized controlled study,70 cases of juvenile FD patients in our hospital were randomly divided into control group and treatment group with 35 cases in each;The control group was given oral domperidone tablets and the treatment group was given oral short-acting insulin with dose of 0.9U/（kg＇d） for 28 days. The clinical efficacy, changes of blood glucose and serum potassium of the two groups were observed to evaluate the efficacy and safety. Results The effective rates of the control group and the treatment group were 42.9% and 88.6% respectively after treatment of 28 days and the difference was statistically significant （P〈 0.01 ）. The incidence of low blood glucose and high blood glucose were all zero in the two groups, and there was no significant difference in serum potassium after treatment （P〉0.05）, Conclusion The adjuvant treatment of juvenile functional dyspepsia with oral insulin has significant clinical efficacy and good safety.