微创经皮椎体成形术在控制脊柱转移性肿瘤围术期感染中的效果观察

Effect of minimally invasive percutaneous vertebroplasty on infection control of spinal metastatic tumors during perioperative period

目的探讨微创经皮椎体成形术在控制脊柱转移性肿瘤围术期感染中的效果。方法选取2008年2月-2010年10月进行治疗的26例脊柱转移性肿瘤患者为研究对象,将其根据手术方式分为A组:开放式椎体后凸成形术组,B组:微创经皮椎体成形术组,每组各13例;将两组患者的感染发生率及手术前后的血清CRP、IL-6、IL-8及TNF-α水平进行统计及比较。结果感染发生率A组为23.1%、B组为0;B组术后1、3 d血清CRP为(27.86±6.34、13.24±4.68)mg/L,IL-6为(176.50±13.05、98.77±9.86)ng/L,IL-8为(298.64±23.56、156.41±25.60)ng/L,TNF-α为(23.24±4.01、15.09±3.50)ng/L;A组CRP(18.12±5.06、8.76±2.15)mg/L,IL-6为(113.02±12.45、72.37±10.87)ng/L,IL-8为(245.96±22.38、102.34±23.14)ng/L,TNF-α为(16.20±2.78、9.46±2.96)ng/L;B组水平均低于A组,差异有统计学意义(均P<0.05)。结论微创经皮椎体成形术,在控制脊柱转移性肿瘤围术期感染中的效果较好,优势明显。

OBJECTIVE To study the effect of minimally invasive percutaneous vertebroplasty in infection control of spinal metastatic tumors during perioperative priod.METHODS A total of 26 patients with spinal metastatic tumors from Feb 2008 to Oct 2010 were selected as research object,and they were divided into group A（open percutaneous kyphoplasty group）13 cases and group B（minimally invasive percutaneous vertebroplasty group）13 cases,then the infection rate and serum CRP,IL-6,IL-8,TNF-α before and after the surgery were analyzed and compared.RESULTS The infection rate of group B（23.1%）was lower than that of group A（0）,serum CRP（27.86±6.34,13.24±4.68）mg/L,IL-6（176.50±13.05,98.77±9.86）ng/L,IL-8（298.64±23.56,156.41±25.60）ng/L,TNF-α（23.24±4.01,15.09±3.50）ng/L of group B after surgery at first and third day were all lower than those of group A with CRP（18.12±5.06,8.76±2.15）mg/L,IL-6（113.02±12.45,72.37±10.87）ng/L,IL-8（245.96±22.38,102.34±23.14）ng/L,TNF-α（16.20±2.78,9.46±2.96）ng/L,the differences were statistically significant（P〈0.05）.CONCLUSION The effect of minimally invasive percutaneous vertebroplasty in infection control of spinal metastatic tumors perioperative is better,and the advantage is obvious.