Preparation and quality evaluation of vincristine sulfate-loaded PEG-PLGA nanoparticles

Objective To prepare the PEG-PLGA nanoparticles loaded with vincristine sulfate(VCR-loaded PEG-PLGA-NPs) and evaluate their quality.Methods VCR-loaded PEG-PLGA-NPs were prepared by the double emulsion solvent evaporation method.The main experimental factors,which influenced the physical and chemical properties of the nanoparticles,were investigated and optimized.Results Under optimal conditions,the VCR-loaded PEG-PLGA-NPs had an average diameter of 135.9 nm with narrow size distribution.The encapsulation efficiency was 68.2%,while the drug loading capacity was 8.34%.In vitro,VCR was released from the PEG-PLGA-NPs sustainedly for more than 13 days with the total amount of 81%.Moreover,the VCR-loaded PEG-PLGA-NPs were relatively stable,which was confirmed by the stability testing.Conclusion The VCR-loaded PEG-PLGA-NPs are a promising nano drug with controlled release,which can be applied widely.

Objective To prepare the PEG-PLGA nanoparticles loaded with vincristine sulfate （VCR-Ioaded PEG-PLGA-NPs） and evaluate their quality. Methods VCR-Ioaded PEG-PLGA-NPs were method. The main experimental factors, which nanoparticles, were investigated and optimized. prepared by the double emulsion solvent evaporation nfluenced the physical and chemical properties of the Results Under optimal conditions, the VCR-Ioaded PEG-PLGA-NPs had an average diameter of 135.9 nm with narrow size distribution. The encapsulation efficiency was 68.2%, while the drug loading capacity was 8.34%. In vitro, VCR was released from the PEG-PLGA-NPs sustainedly for more than 13 days with the total amount of 81%. Moreover, the VCR-Ioaded PEG-PLGA-NPs were relatively stable, which was confirmed by the stability testing. Conclusion The VCR-Ioaded PEG-PLGA-NPs are a promising nano drug with controlled release, which can be applied widely.