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芍红消结颗粒对子宫内膜异位症大鼠异位组织MMP-2 mRNA表达的影响

Effect of Shaohong Xiaojie Particle on the Expression of MMP-2 mRNA in Rats with Endometriosis
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摘要 目的观察芍红消结颗粒对子宫内膜异位症大鼠异位组织基质金属酶(MMP)-2 mRNA的影响,探讨其治疗子宫内膜异位症的作用机制。方法半定量逆转录聚合酶链反应技术(RT-PCR)检测EM s大鼠模型的异位组织中MMP-2 mRNA的表达。结果芍红消结颗粒小剂量组抑制异位内膜体积增长(P<0.05),降低异位内膜质量(P<0.01),减少异位组织MMP-2mRNA的表达(P<0.01)。结论芍红消结颗粒可通过降低EM s大鼠异位组织MMP-2 mRNA的表达,达到治疗EM s的作用。 OBJECTIVE To explore the mechanism of action of Shaohong Xiaojie particle in the treatment of endometriosis by investigating the expressions of MMP-2 mRNA in ectopic endometriums of rats with endometriosis.METHODS The expression of MMP-2 mRNA was tested by RT-PCR.RESULTS The tow dose-group could restrain the volume of ectopic endometriotic tissue（P0.05）,and also can reduce its weight（P0.01）.The expressions of MMP-2 mRNA was decreased simultaneously（P0.01）.CONCLUSION Shaohong Xiaojie particle can decrease the expressions of MMP-2 mRNA in ectopic endometriums,which may be responsible for its therapeutie effect on endometriosis.
作者 陈诚 谈忠 徐立
机构地区 南京中医药大学 南京市中医院
出处 《中国药学杂志》 CAS CSCD 北大核心 2011年第9期665-667,共3页 Chinese Pharmaceutical Journal
基金 南京市医学科技发展项目(200901086)
关键词 子宫内膜异位症 芍红消结颗粒 基质金属酶 endometriosis Shaohong Xiaojie particle MMP-2
分类号 R965 [医药卫生—药理学]
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参考文献8

  • 1SAMPSON J A. Peritoneal endometriosis due to the menstrual dis- semination of endometrial tissue into the peritoneal cavity[ J]. Am J Obstet Gynecol, 1927, 14:422-469.
  • 2CAOLX SITY HUANGJL.New progress about MMPs/TIMPs in the studies of EMS.广东医学,2007,28(5):832-834.
  • 3JONES R C. The effect of a luteinizing hormone releasing hormone (LRH) agonist ( Wy-40,972 ), levonor-gestrel, danazol and ovari- ectomy on experimental endometriosis in the rat [ J ]. Acta Endocri- nologica, 1984,106 (2) :282-288.
  • 4徐昕红,于榕,贡沁燕,姚明辉.缓释醋酸亮丙瑞林微球对大鼠子宫异位内膜的抑制作用[J].中国临床药理学与治疗学,2004,9(8):876-879. 被引量：3
  • 5LAMBERT V, WiELOCKX B, MUNAUT C, et al. MMP-2 and MMP-9 synergize in promoting choroid'al neovascularization [ J ]. FASEB J,2003,17 ( 15 ) :2290-2292.
  • 6OSTEEN K G, BRUNER TRAN K L, ONG D, et al. Paracrine mediators of endometrial matrix metalloproteinase expression: po- tential targets for progestin-based treatment of endometriosis [ J]. Ann N Y Acad Sei, 2002,95 ( 5 ) : 139-146.
  • 7GARGETT C E, ROGERS P A. Human endometrial angiogenesis [J]. J Soc Reprod Fert, 2001,121 (2) :181-186.
  • 8BRUNER K L, EISENBERG E, GORSTEIN F, et al. Progester- one and transforming growth factor-beta coordinately regulate sup- pression of endometrial matrix metal loproteinases in a model of ex- perimental endometriosis[ J ]. Steroids, 1999,64 ( 9 ) :648-653.

二级参考文献12

  • 1陈丙莺,马建吟,黄钦田,尤丽芬.简易自然杀伤试验——LDH释放改良法[J].上海免疫学杂志,1989,9(4):218-219. 被引量：104
  • 2周美华,杨隽,林加宝,邱秀娣,褚云鸿,龚岳亭.丙氨瑞林对下丘脑-垂体-性腺轴作用的研究[J].中国医药工业杂志,1997,28(1):18-23. 被引量：3
  • 3[1]Jones RC. The effect of a luteinizing hormone releasing hormone (LRH) agonist, levonorgestrel, danazol and ovariectomy on experimental endometriosis in the rat[J]. Acta Endocrino, 1984;106(2) :282 - 8
  • 4[2]Zarrow MX. Experimental Endocrinology[M]. New York:Academic Press, 1964:24
  • 5[6]Dmowski WP, Gebel H, Braun DP. Decreased apoptosis and sensitivity to macrophage mediated cytolysis of endometrial cells in endometriosis[J]. Hum Reprod Update, 1998;4(5) :696 -701
  • 6[7]Tsudo T,Harada T,Iwabe T, Tanikawa M,Nagano Y, Ito M, et al. Altered gene expression and the section of interleukin-6 in stromal cells derived from endometriotic tissues[J]. Fertil Steril, 2000;73(2):205 - 11
  • 7[8]Witz CA. Interleukin-6: another piece of the endometriosis-cytokine puzzle[J]. Fertil Steril, 2000;73(2) :212 - 4
  • 8[9]Pellicer A, Albert C, Mercader A, Bonilla MF, Remohi J, Simon C. The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production[J]. Fertil Steril, 1998;70(3) :425 - 31
  • 9[10]Iwabe T, Harada T, Tsudo T, Nagano Y, Yoshida S, Tanikawa M, et al. Tumor necrosis factor alpha promotes proliferation of endometriotic stromal cell by inducing interleukin-8 gene and protein expression[J]. J Endocrinol Metab, 2000; 85 (2): 824-9
  • 10[11]Batticane N, Morale MC, Gallo F, Farinella Z, Marchetti B, Batticane N. Luteinizing hormone-releasing hormone signaling at the lymphocyte involves stimulation of interleukin-2 receptor expression[J]. Endocrinol, 1991; 129( 1 ):277 - 86

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中国药学杂志
2011年 第9期

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