3,3′,5,5′-联苯四甲酸的合成

Synthesis of 3,3′,5,5′-biphenyltetraacid

以间苯二甲酸为原料经硝化、还原和重氮化-偶联反应合成标题化合物,并对硝化、还原和重氮化-偶联反应进行了优化。间苯二甲酸经硝化、还原反应合成了5-氨基间苯二甲酸,再经重氮化-偶联反应合成标题化合物,总收率>63.2%(以间苯二甲酸计)。该路线反应条件温和、收率较高,具有工业应用潜力。

3,3′,5,5′-Biphenyltetraacid was synthesized from isophthalic acid via nitration,deoxidization and diazotization-coupling.The synthetic conditions of nitration,deoxidization and diazotization-coupling were optimized.Firstly,5-aminoisophthalic acid was prepared from isophthalic acid via nitration and deoxidization with a yield of 86.4%.Then 3,3′,5,5′-biphenyltetraacid was obtained by the coupling of diazonum which was made from the diazotization of 5-aminoisophthalic acid,with a yield over 73.1%.Total yield based on isophthalic acid was over 63.2%,this route is run at mild reaction condition with high yields and has a good industrial application potential.