黄花紫玉盘枝、叶中的生物碱和蒽醌类化合物

Alkaloids and anthraquinones from branches and leaves of Uvaria kurzii

目的：对黄花紫玉盘Uvaria kurzii枝、叶的化学成分进行分离鉴定,并进行体外细胞毒活性筛选。方法：以硅胶和Sephadex LH-20色谱柱进行分离纯化,根据理化性质和波谱数据鉴定化合物结构。采用MTT法对所得化合物进行5种人肿瘤细胞系的生物活性检测。结果：分离鉴定了9个化合物,分别为bidebiline A（1）,annobraine（2）,oxoputerine（3）,athero-spermidine（4）,鹅掌楸碱（5）,大黄素甲醚（6）,大黄素-8-甲醚（7）,甲基异茜草素-1-甲醚（8）,大黄素（9）。结论：化合物14,69为本属中首次分到。体外活性筛选结果表明35对A549,Bel7402,BGC823,HCT-8,A2780等多种癌细胞有生长抑制作用。

Objective：To investigate the chemical constituents of the branches and leaves of Uvaria kurzii.Method： The compounds were isolated and purified by silica gel and Sephadex LH-20 column chromatographic methods.Their chemical structures were elucidated on the basis of physicochemical properties and spectral data.Result： Nine compounds were isolated and identified as： bidebiline A（1）,annobraine（2）,oxoputerine（3）,atherospermidine（4）,liriodenine（5）,physcion（6）,questin（7）,rubiadin 3-methyl ether（8）,emodin（9）.Conclusion： Compound 1-4,6-9 were isolated from the genus Uvaria for the first time.Compound 3-5 showed inhabitation activities against tumor cell lines A549,Bel7402,BGC823,HCT-8,A2780,respectively.