牛膝总皂苷对卒中型自发性高血压大鼠的影响

Therapeutic effects of saponins from Achyranthes bidentata in SHRsp

目的:牛膝总皂苷对卒中型自发性高血压大鼠(SHRsp)卒中后血压、存活时间及平均寿命、神经症状、脑系数的影响。方法:将SHRsp大鼠随机分为牛膝总皂苷高、中、低剂量组(0.40,0.20,0.10 g.kg-1)、华佗再造丸组(2.5 g.kg-1)和模型组,正常组为SD大鼠,每组10只,连续给药20 d。观察牛膝总皂苷对SHRsp卒中后血压、神经状态变化、死亡率、脑系数及对海马区神经元的影响。结果:牛膝总皂苷可降低SHRsp大鼠血压,改善SHRsp脑卒中后的神经症状,延长卒中后存活时间,降低脑系数,降低脑卒中后大鼠死亡率,保护海马区神经元。结论:牛膝总皂苷对实验性SHRsp脑卒中有一定治疗作用。

Objective：To study the therapeutic effects of saponins from Achyranthes bidentata（SAB） in stroke-prone sponyaneously hypertension rats（SHRsp）.Method： Sixty SHRsp were randomly divided into five groups： SAB 0.10,0.20,0.40 g·kg-1,Huatuo Zaizao pill group（positive control group）2.5 g·kg-1 and pathologic group（n=10）.SAB and Huatuo Zaizao pill were used through filing stomach everyday for 20 days,pathologic group was given distilled water.The effects of SAB on blood pressure,changes of nerve state,death rate,brain index and the pathologic changes of hippocampal neuron of SHRsp were observed.Result： SAB could markedly decrease brain index,death rate of SHRsp after stroke.SAB could improve nerve state of SHRsp after stroke.Also SAB could prolong survival time and prevent pathologic change of hippocampal neuron of SHRsp after stroke.Conclusion： SAB is advantageous of therapying the stroke in SHRsp.