食管鳞癌遗传易感性与基质金属蛋白酶-1基因多态性的关系

Polymorphism of the matrix metalloproteinase-1 and risk of esophageal squamous cell carcinoma

目的探讨基质金属蛋白酶-1（MMP-1）基因多态性与食管鳞癌发病风险的关系。方法运用聚合酶链反应一限制性片段长度多态性（PCR—RFLP）分析方法检测450对病例与对照中MMP．1的lG／2G基因多态性。结果与1G等位基因携带者（包括1G／1G及1G／2G基因型）比较，2G／2G基因型携带者与食管鳞癌显著相关[OR=1．39；95％可信区间（CI）：1．06～1．81]。此外，食管鳞癌的发病风险在吸烟者及女性中更加显著，其OR及95％C1分别为1．59（1．09～2．31）及1．76（1．05～2．97）。结论MMP-1基因多态性可能在食管鳞癌的发生过程中起到一定作用。

Objective Our study aimed to test the association between the matrix metalloprotemase-1 （MMP-1） polymorphism and risk of esophageal squamous cell carcinoma （ESCC）. Methods We determined the MMP-1 polymorphism in 450 ESCC cases and 450 frequency-matched controls by polymerase chain reaction-based restriction fragment length polymorphism （PCR-RFLP）. Results We found evidence for a significant association between the 2G/2G genotype and ESCC risk compared with 1G allele, including 1G/1G genotype and 1G/2G genotype [ OR = 1.39;95% confidence interval （CI） , 1.06-1.81 ]. Furthermore,the increased risk was found to be in smokers （ OR,1.59 ;95% CI,1.09-2. 31 ） and in female （OR, 1.76;95% CI, 1.05-2. 97）. Conclusion Our study suggests that the MMP-1 promoter polymor- phism may play a role in the etiology of ESCC.