肌动蛋白交联蛋白与血管内皮生长因子在肾细胞癌中的表达及其相关性

Correlation of Fascin and vascular endothelial growth factor with the biological behaviors of renal cell carcinoma

目的探讨肌动蛋白交联蛋白（Fascin）与血管内皮生长因子（VEGF）在肾细胞癌组织的表达及与其生物学行为的关系。方法采用免疫组织化学sP法检测Fascin与VEGF在92例肾细胞癌组织及20例正常肾脏组织中的表达。结果Fascin及VEGF在肾细胞癌组织中的表达阳性率明显高于正常肾组织（P〈0．05）；肾细胞癌组织中两种蛋白的表达与肿瘤组织学分级和临床分期均呈正相关（P〈0．05）；与年龄、性别及肿瘤病理类型无明显相关（P〉0．05）。且Fascin和VEGF的表达之间呈正相关（P〈0．05）。结论Fascin与VEGF可作为反映肾细胞癌生物学行为的参考指标。

Objective Toinvestigate the expression of Fascin and vascular endothelial growth factor （VEGF） in renal cell carcinoma （RCC） and the correlation with the biological behaviors. Methods The immunohistochemistry staining method was used to detect the expression of Fascin and VEGF in 92 cases of RCC and 20 cases of normal renal tissues as controls. Results The expression of Fascin in carcinoma tissue was significantly higher than that in normal tissues （ P 〈 0. 05 ）. Positive expression of Fascin and VEGF in renal cell carcinoma tissue was correlated with tumor grade （ P 〈 0. 05 ） and clinical stage （ P 〈 0. 05 ） , but not with age, gender and different histological categories （ P 〉 0. 05 ）. There was also a positive correlation between Fascin and VEGF （P 〈 0. 05 ）. Conclusion Fascin and VEGF are objective markers to estimate the behaviors of renal cell carcinoma.