摘要
胶质瘢痕是神经系统损伤后由反应性星形胶质细胞,小胶质细胞及其分泌的细胞外基质组成。早期的研究多集中于胶质瘢痕在抑制轴突生长,神经细胞再生等方面的作用。而最新的研究表明胶质瘢痕的形成对损伤急性期神经细胞具有重要的保护作用。本文从瘢痕组织在损伤缝合和组织重构、局部免疫调节、神经再生等方面对神经损伤的保护作用进行综述。
The glial scar consists predominately of reactive astrocytes,microglia and exracellular matrix molecules after center nervous system（CNS） injury.Early studies focused on scar tissue formation inhibiting axonal growth and regeneration.However,increasing evidence indicates that scar tissue and its components might play an important role in the immediate response to CNS injury.Here we reviewed the protective effects of glial scars on sealing the site of injury and remodeling,controlling the local immune response and on neurogenesis.
出处
《生命的化学》
CAS
CSCD
北大核心
2011年第2期272-276,共5页
Chemistry of Life
基金
国家自然科学基金资助项目(30873198)资助
