摘要
目的:考察舒血宁注射液分别与5%葡萄糖注射液和果糖注射液配伍后,混合液放置时间与药物稳定性的关系。方法:模拟临床用药浓度,在室温(25℃)下将舒血宁注射液20mL分别与250mL5%葡萄糖、果糖注射液配伍,放置0、1.0、1.5、2.5、3.5h后考察配伍液的性状、pH值、不溶性微粒与吸光度的变化。结果:舒血宁注射液分别与5%葡萄糖注射液、果糖注射液配伍后,性状、pH值无明显变化,吸光度、不溶性微粒都存在着不同程度的变化。结论:在室温25℃时,舒血宁注射液与5%葡萄糖注射液配伍后建议在1.5~2h内使用;果糖注射液最好单独使用。
OBJECTIVE:To compare the relationship of mixture storage time with drug stability after Shuxuening injection mixed with 5% Glucose injection and Fructose injection. METHODS:At room temperature(25 ℃) ,Shuxuening injection 20 mL was mixed with 5% Glucose injection and Fructose injection 250 mL. The changes of property and pH value of mixture,insoluble particle and absorbance were observed after 0,1.0,1.5,2.5,3.5 h. RESULTS:After mixing,property and pH value of mixture had no significant change while insoluble particle and absorbance changed to some extent. CONCLUSION:At 25 ℃ Shuxuening injection can be mixed with 5% Glucose injection,which is applicable within 1.5~2 h. It is better to use Fructose injection alone.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第19期1792-1793,共2页
China Pharmacy