冠心宁注射液辅助治疗不稳定型心绞痛的Meta分析

Meta-analysis of Guanxinning Injection as Adjunctive Therapy for Unstable Angina Pectoris

目的:评价冠心宁注射液辅助治疗不稳定型心绞痛(UAP)的临床疗效。方法:计算机检索Medline、EMBase、Cochrane图书馆、CBM、VIP、CNKI、万方数据库,纳入冠心宁注射液治疗UAP的随机对照试验(RCT),对纳入研究进行质量评价,并对研究数据进行Meta分析。结果:纳入9个RCT,均为C级。Meta分析结果显示,心绞痛症状改善显效率差异有统计学意义[RR=1.48,95%CI(1.24,1.76)]、心电图改善显效率差异无统计学意义[RR=1.39,95%CI(0.97,1.99)]。结论:在常规治疗基础上加用冠心宁注射液治疗UAP能够提高心绞痛症状和心电图改善的显效率。

OBJECTIVE：To evaluate the clinical efficacy of Guanxinning injection as adjunctive therapy for unstable angina pectoris（UAP） . METHODS：Randomized controlled trials（RCT） of Guanxinning injection as adjunctive therapy for UAP were gathered from Medline,EMBase,Cochrane Library,CBM,VIP,CNKI and Wanfang databases. The quality of included studies was evaluated and meta-analysis was carried out. RESULTS：9 RCTs were included,all were graded C. Meta-analysis indicated that the excellence rate of symptom improvement of angina pectoris had significant difference（RR=1.48,95%CI[1.24,1.76]） . The excellence rate of electrocardiogram improvement had no significant difference（RR=1.39,95%CI[0.97,1.99]） .CONCLUSION：Guanxinning injection combined with conventional treatment for UAP could improve angina pectoris symptom and excellence rate of electrocardiogram improvement.